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Before inclusion in NBS, many patients died during the first years of life often without any prior signs

Measurable nerve function improvements on objective testing typically require 3 to 6 months of consistent protocol adherence

Intramuscular injection delivers B12 directly into tissue, which is critical for patients whose digestive systems cannot absorb oral supplements effectively

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To date, most TPD reagents incorporate ligands for either von Hippel-Lindau (VHL) or Cereblon (CRBN) that are assembled with CUL2-RBX1 and CUL4-RBX1, respectively 2