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Clinical recommendations based upon the patient's renal function include [see Dosage and Administration (2.2), Clinical Pharmacology (12.3)]: Before initiating JANUMET, obtain an estimated glomerular filtration rate (eGFR)

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139,140 The UPR relieves cellular load by reshaping the capacity for ER synthesis

Some people experience suicidal thoughts because of the pain

The psychological impact shouldn't be underestimated, as anxiety and depression can accompany these physical effects