In humans, the SHMT enzyme exists in two isoforms, with the cSHMT gene encoding the cytosolic/nuclear enzyme (cSHMT) and the mSHMT gene encoding a mitochondrial SHMT enzyme
[1] [9] Sermorelin , by contrast, was FDA-approved decades ago (Geref, 1997) but the manufacturer voluntarily withdrew it in 2008, and the FDA determined that withdrawal was not for reasons of safety or effectiveness
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doi: 10.1016/j.dld.2014.01.159 83 TofaloRCocchiSSuzziG
Textbook of Medical Physiology (11th ed.)