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38 Studies 39 have shown that GERD patients with lower HRV values exhibit a decrease in parasympathetic components and an increase in sympathetic components, indicating vagal dysfunction

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This nonapeptide, first isolated from the cerebral venous blood of rabbits during sleep, has been shown to induce slow-wave sleep, modulate pain perception, and exhibit potential antioxidant and immunomodulatory properties

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By 2026, we may also see their application in treating sleep apnoea and even certain neurodegenerative conditions