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In aged research models, Epithalon administration has been associated with restored nighttime melatonin peaks, improved circadian rhythm amplitude, and normalization of cortisol secretion patterns

29 Clinical trials assessing the efficacy of LOLA showed that it is at least comparable (sometimes superior) to other interventions (such as lactulose or oral antibiotics), in addition to being well-tolerated and associated with improvement in quality of life

they will know the concentration and the volume per dose

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