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2008 Jul 22;118(4):e81 Bethel MA, Patel RA, Merrill P, Lokhnygina Y, Buse JB, Mentz RJ, EXSCEL Study Group et al (2018) Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis

These results demonstrate that TGF--induced transition from fibroblasts to myofibroblasts involves canonical TGF-/Smad2/3 signaling, non-canonical TGF-/ERK1/2 signaling, and ROS production via NAD(P)H oxidase

Current evidence is preliminary and consists mainly of observational reports, case studies, and animal research rather than randomized controlled trials