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Once damage has begun, its important to reduce the total body uric acid level, which, by equilibration, causes uric acid to move out of the joints

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investigated the effects of TMAO on glucose tolerance in high fat diet (HFD)-fed mice, they found that dietary TMAO exacerbates impaired glucose tolerance, blocks the insulin signaling pathway in the liver, and led to adipose tissue inflammation in mice (Gao et al., 2014)