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GLP-1 Receptor Agonists (e.g., semaglutide, liraglutide) Increase insulin secretion in response to food Reduce glucagon release (which lowers blood sugar) Slows gastric emptying (which helps with post-meal glucose excursions) Reduces appetite and induces satiety which leads to weight loss GLP-1/GIP Receptor Agonists (e.g., tirzepatide) GLP-1 effects (same as above) GIP effect: further enhances insulin secretion Both medications help with blood sugar control and weight loss, but Mounjaros dual mechanism may offer stronger effects on insulin secretion, which improves A1c levels

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While both lipotropic and semaglutide injections may be used for weight loss, medical experts say semaglutide injections have more drastic results and more research to support their effectiveness than lipotropic injections

In early 2025, the FDA ended the semaglutide shortage designation, which means compounding pharmacies no longer have the legal basis to produce copies of the drug