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A reduced initial dose should be considered for patients known to be homozygous for the UGT1A1*28 alleleHowever, the precise dose reduction in this patient population is not known 43 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Other polymorphisms of UGT due to random genetic differences have been reported, but only a few have suggested to influence drug metabolism in the clinic.e.g

Additionally, hypoglycaemia, which can occur particularly when Mounjaro is used with insulin or sulfonylureas, is an important differential diagnosis for dizziness in people with diabetes

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This is common and does not reflect a lack of willpower or effort