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Sugiyama C, Yamamoto M, Kotani T, et al

4.4 Neonatal hypoxicischemic encephalopathy The pathophysiology of HIE involves hypoxicischemic injury, characterized by perturbations in mitochondrial dynamics and the inhibition of critical energy-producing pathways, including oxidative phosphorylation and fatty acid -oxidation (54)

Unlike NSAIDs such as ibuprofen, it does not have significant peripheral anti-inflammatory activity and is therefore not appropriate as a primary treatment for inflammatory arthritis (e.g., rheumatoid arthritis)

It provides deep hydration and smooths skin texture

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