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By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

Researchers often investigate peptides like DSIP to better understand how neurological and hormonal signaling systems may interact with these biological rhythms

This combination of direct fat cell targeting, muscle preservation, metabolic selectivity, and favorable safety profile makes AOD-9604 a distinctive option among metabolic peptides and body composition interventions

doi: 10.1016/S0140-6736(23)01163-7 76 GarveyWTBlherMOsorto ContrerasCKDaviesMJLehmannEWPietilinenKHet al

Different peptides target different pathways