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demonstrated that increased IGF-1 levels are associated with trastuzumab resistance [118], recent focus has turned into clarifying the cross-talk between the IGF-1 system and the Epidermal Growth Factor Receptors (EGFR) family

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Instead of saying "I feel sick some days," you can say "My symptoms correlate precisely with predicted concentration peaks, suggesting a lower peak via dose splitting might resolve them while maintaining therapeutic trough levels." That is the kind of data-driven conversation that leads to better outcomes