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This is revealing, as abnormalities in circadian rhythms are considered to play a potential underlying role in bipolar disorder, as many genes associated with bipolar disorder including CLOCK , PER3 and BMAL1 are regulated in a circadian manner [70,71,72]

The in vitro hippocampal-neuron-culture spine-density work used Dihexa concentrations across a wide range, with effects observed at picomolar concentrations [2]

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