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This is attributed to the shame and impaired self-esteem caused by hair loss, which can affect appearance (54, 55)

The methionine overload would tend to decrease basal hyperhomocysteinemia rather than cause a further increase in basal hyperhomocysteinemia in patients bearing remethylation defects such as folate deficiency (associated or not with the C677T mutation of the MTHFR gene) (Durand et al, 1997a

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