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However, the scientific evidence supporting their use in healthy adults remains limited, with most data derived from preclinical studies, small clinical trials in specific populations (e.g., sarcopenia or HIV-associated wasting), or off-label applications
The dosages used in the RCTs that showed benefits ranged from 600 to 2700 mg per day for 412 weeks
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Native GLP-1 is cleaved by DDP-4 directly after 7His and 8Ala, 2 N-terminal amino acids
This suggests that non-responders were less severely affected by ME/CFS at baseline, and that the main positive effect of nasal B12 administration occurs in more severely affected patients
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