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It is possible that under specific environmental or nutritional conditions, these variants may confer subtle adaptive advantagesan idea that warrants further exploration through longitudinal and mechanistic studies

In conclusion, tolerability, safety, metabolism and pharmacokinetics of SB and SPA in CPSS dogs are comparable to healthy dogs and humans (with the exception of PAGL being the end product of PAA in dogs rather than PAG in humans)

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This peptide sequence includes two binding domains (epitopes) that interact with the c-Mpl receptor of the thrombopoietin receptor, each domain composed of 14 amino acids (IEGPTLRQWLAARA)