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10.1016/j.neuron.2005.01.003 55 HonkuraN.MatsuzakiM.NoguchiJ.Ellis-DaviesG

It should be noted, however, that ALDH1A1, but not CYP2E1, is a downstream target of NRF2, which was found to be activated in untreated GCLM KO mouse liver

The association of ROS with neuronal degeneration in PD is further substantiated by modeling the Parkinsonian phenotypes in animals through 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, 1,1-dimethyl-4,4-bipyridinium dichloride (paraquat), or 6-hydroxydopamine (6-OHDA), those are known of elevate the oxygen free-radicals in the cell 18

International Journal of Molecular Sciences, 19(7):1987