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TB-500's pharmacokinetics reflect its actin-binding behavior

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Philp and colleagues (FASEB J, 2003, PMID 14500546) showed the LKKTETQ actin-binding motif at residues 17 to 23 is sufficient to promote endothelial cell migration in aortic ring and chorioallantoic assays, and Bock-Marquette and colleagues (Nature, 2004, PMID 15565145) reported integrin-linked kinase and Akt activation in mouse cardiac models

The durability of vaccine protection is another key area that requires a better understanding of the fundamentals of immune memory, a key question being how can we limit the acute contraction of the adaptive immune response after prophylactic vaccination and limit attrition of long-term memory , in particular for nAb titers in the blood?