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A randomized, double-blind, placebo-controlled clinical trial conducted in 30 healthy Filipino women aged 3050 years has provided some evidence favouring the efficacy of topical 2% GSSG lotion in temporary skin lightening

However, opportunities to benefit from these advancements have been limited for many groups

Of these, two reported lower activity [63, 71] and two reported no significant difference between cases and controls [74, 84]

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