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The long half-life means you still have circulating cagrilintide even several days after a missed dose, though at reduced levels

7 Principal component and pathway enrichment analysis

It inhibits the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12) and modulates macrophage polarization towards the M2 phenotype (reparative/anti-inflammatory)

However, this principle assumes that there is no other direct effect of the genetic variants on the risk of cancer that goes via alternative ways (either directly affecting cancer growth or by affecting some confounder)

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