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545 NLRP6 also regulates the secretion of IL-18 and antimicrobial peptides in enterocytes, 546 as well as mucin production in goblet cells, 547 which contributes to its ability to prevent the invasion of pathobionts that initiate colitis-associated colorectal cancer 548 (Fig

Regulation of PRRs While innate signaling plays a vital role in host defense, maintaining a balanced PRR signaling outcome is critical for effectively eliminating invading pathogens while avoiding excessive immunopathology