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Additionally, tapering NE before reducing the AVP infusion rate could potentially prevent rebound hypotension [21, 22], although this approach is not consistently implemented, and the influence of other factors that mitigate the risk of rebound hypotension during recovery remains unclear
Rodent healing differs from human healing in various ways, and dose extrapolation involves assumptions that may not hold perfectly
The investigators interpreted the findings as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in the Kraus 2014 genetic-validation study
Furthermore, patients who metabolize testosterone more rapidly, a phenomenon sometimes observed due to genetic enzyme variations, may experience quicker drops between injections
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