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This is one reason why age spots are common as we grow older

On other hand, prooxidant therapies, including ionizing radiation and chemotherapeutic agents, are widely used in clinics, based on the rationale that a further oxidative stimulus added to the constitutive oxidative stress in tumor cells should, in fact, cause the collapse of the antioxidant systems, leading to cell death [6]

Thr180/Tyr182, D13.14.4E

During the acute phase of the virus, the immune system launches a massive inflammatory response, generating enormous amounts of reactive oxygen species (ROS) to destroy the invading pathogen

Both ATF4 and ATF3 bind to these elements, with ATF4 binding primarily to the ATF/CRE site and the ACM site, especially under stress conditions, while ATF3 binds to the ATF/CRE site in both basal and stress conditions