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In this study, we investigated the underlying cellular mechanisms to decipher how GLP1-R agonists exendin-4 and semaglutide protect the brain in vitro using primary neurons exposed to oxygen-glucose deprivation (OGD) to induce HI, and in vivo where HI was induced by unilateral carotid occlusion in P10 CD1 mice, and either saline, exendin-4 or semaglutide were given immediately after HI
Given the pronounced effect of tau elimination observed in in vitro and in vivo studies, selecting patients who test positive for tau biomarkers (CSF, blood, or positron emission tomography) could enhance the likelihood of achieving significant disease modification
A patient with favorable GLP-1 receptor variants may experience stronger appetite suppression and lower rebound risk, while someone with FTO risk variants may need more structured behavioral support during and after treatment
doi: 10.1210/jcem.85.8.6738 24 EythEBasitHSwiftCJ
