why do glp-1 drugs stop working fail to cause fat loss in some? A mitochondrial switch ("SLC25A45") controls whether mitochondria burn fat or carbohydrate, and removing it (in mice) makes GLP-1 drugs Weight loss: Study finds keys

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Regulatory approvals differ by age: liraglutide and semaglutide are approved for adolescent obesity ( 12 years) in multiple jurisdictions, but their use in younger children represents off-label prescribing

These findings underscore FSP1s independent role in tumor maintenance and its potential as a stand-alone therapeutic target

Both substances are processed through the same liver pathway, and overlapping them even with residual alcohol still in the system raises the risk of liver toxicity