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The harder population to reach is the one without a diabetes diagnosis, members who are overweight or have obesity and carry cardiovascular risk, perhaps taking a statin or a blood pressure medication, but whose A1C hasn't yet crossed the threshold for a diabetes diagnosis

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Diminished levels of monoamines, altered sensitivity of receptors, and dysregulated transport mechanisms such as SERT and NET play a significant role in the manifestation of depressive symptoms (24)