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In Rac1 conditional KO mice where Rac1 was deleted in mature neurons, working memory in the delayed matching-to-place (DMP) water maze test was impaired ( Drosophila (Shuai et al., 2010) where controlled expression of dominant negative and constitutively active Rac1 mutants in the MBs using the Gal/UAS binary system delayed and facilitated aversive olfactory memory decay, respectively, without affecting memory acquisition (Shuai et al., 2010)

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Notably, expression of drug effects appears generally more robust when comparing relative as compared with absolute values, which is a common problem in biomedical sciences that resides in the typically observed greater data variability in absolute versus relative data

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