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Moreover, a phenotypic study on human primary macrophages and stellate cells suggested that AXA1125 can inhibit lipopolysaccharide (LPS)-induced TNF- expression in M1 macrophages and increase the secretion of anti-inflammatory chemokine C-C motif ligands by M2 macrophages, as well as reduced Pro-C3 and HSP47 expression in HSC

Logistic regression was performed using both Python (Python Software Foundation, Wilmington, Delaware, USA) and R 3.4.4 software (R Foundation for Statistical Computing, Vienna, Austria) to ensure the outputs matched, and the order of the rows in the covariate matrix was randomised to eliminate this bias

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Using more water (e.g., 4mL) dilutes it further, requiring a larger volume per dose, which can be easier to measure precisely