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Transgenic murine models for cognition Beyond chemical lesion models (scopolamine, 192-IgG-saporin), cognitive research has an arsenal of genetically modified strains that reproduce specific cognitive phenotypes: Alzheimer models 3xTg-AD (LaFerla): triple transgenic APP Swedish, PS1 M146V, tau P301L

Among the newly developed compounds, 49, 50, 51, and 52 (Figure 35) were found to be the most effective inhibitors of PGE2 and NO production induced by LPS

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