Stierman B, Afful J, Carroll MD, et al
Semaglutide is the synthetic version of a naturally occurring human hormone, called Glucagon-like peptide 1 or GLP-1 that has been modified so that it is less likely to be broken down and therefore has a longer duration of action
Changes in cortisol can interfere with the regular pulsatile release of gonadotropin-releasing hormone (GnRH), disrupting the normal menstrual cycle
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Instead of escalating every 4 weeks, increases happen every 6-8 weeks in smaller increments (1.0-1.5 mg instead of 2.5 mg)