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A clinical trial by Meissner and colleagues with the GLP-1 lixisenatide demonstrated a modest reduction in motor disability progression in patients with early-stage PD

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These transporters all adopt the major facilitator superfamily (MFS) fold and are capable of translocating a range of different molecules across the plasma membrane, including endogenous substrates, clinically relevant drugs and xenobiotics 12

Ozempic is a common brand-name medication used for blood sugar management and weight loss, while tramadol is a synthetic opioid used to manage pain