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5-Amino-1MQ instead removes a drain on that route: by inhibiting NNMT it prevents nicotinamide from being methylated to 1-methylnicotinamide, leaving it available for NAMPT and the salvage pathway, and simultaneously spares the S-adenosyl-L-methionine that the methylation would have consumed

Patients need to make decisions under conditions of uncertainty, informed by the best available data and their own risk-benefit assessment

These concerns necessitate further research, including dedicated long-term safety studies in animal models, specifically designed to assess potential risks associated with higher doses and prolonged exposure

3, May 2015, pp