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The natural pulsatile pattern of GH secretion appears to be important for some of GHs effects lipolysis, for example, responds more robustly to pulsatile GH than to constant GH levels

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Biophys Biochem Res Commun 2005;338:55867

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Mitochondria, as the primary source of ROS in mammalian cells, are particularly vulnerable, with oxidative stress contributing to mitochondrial dysfunction, energy depletion, and cell death (Cui et al., 2012)

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