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In summary, GLP-1 RAs, through weight loss and the reduction of pro-inflammatory cytokines [31, 33], could provide a complementary approach to standard therapies for HS, especially in patients with obesity [36]

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Although a low concentration of homocysteine in its reduced form behaves as a pro-oxidant, in high concentration, homocysteine, like other thiols, presents a free-radical scavenger activity (Munday, 1989)

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The GIP component enhances the insulin-secreting effects of GLP-1, while the glucagon component is thought to increase energy expenditure and fat oxidation