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Conversely, other studies have demonstrated that lactic acid may partially restore PGC-1 activity, reduce the expression of pro-inflammatory cytokines including TNF-, IL-1, and IL-6, alleviate renal injury, and improve survival in murine models of sepsis-induced AKI (Takakura and Zandi-Nejad, 2019)

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In general, compliant patients who fail to respond to iron therapy may be referred to a hematologist for further evaluation of the anemia or a gastroenterologist for possible malabsorption or occult blood loss