In parallel, synthetic biology approaches explore LR3 analogs with modified IGF-1R affinity, increased selectivity versus the insulin receptor, or biased activation of specific signaling pathways (pMAPK versus pAkt) to dissociate proliferative from metabolic effects
Goodman WK, Price LH, Rasmussen SA
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This evaluation was performed through an assessment of the expression of different surface molecules such as: CD13, CD29, CD44, CD73, CD90, CD105, and markers CD14, CD34, and CD45 [38]