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A 2025 study reported that 22% of GLP-1 RA users were diagnosed with at least one new nutrient deficiency by the 12-month mark, and another analysis found significant declines in the intake of multiple key nutrients especially iron, magnesium, calcium, potassium, vitamins A, C, D, E, K, and B12

Keywords: GLP-1, GLP-1 RA, T2DM, hypoglycemia Introduction The word incretin was coined by the Belgian physiologist La Barre 1 to describe gut hormones that stimulated pancreatic hormone secretion and proposed it in diabetes treatment

Briefly, GLP-1 exists in the human body in two active forms, GLP-1 (7-36 amide) and GLP-1 (7-37), with the proportion of GLP-1 (7-36 amide) being higher (8, 9)

Additional antioxidant support linked to enhanced glutathione levels includes ALA (alpha-lipoic acid) and Vitamin E