Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]
doi:10.1210/endo.142.12.8522 Heffernan MA, Thorburn AW, Fam B, et al
Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight
patients with more adipose tissue at the injection site do not need a longer needle, since subcutaneous tissue is typically reached within the first few millimeters of insertion
Let's look at how that translates to dosing with a U-100 syringe: 5mg is in 100 units (1 mL) 1mg is in 20 units (0.2 mL) 0.5mg is in 10 units (0.1 mL) As you can see, a 1mg dose now requires twice the volume (20 units instead of 10)