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Unravelling the molecular basis for cardiac iron metabolism and deficiency in heart failure

Genes involved in antioxidant defense and the ubiquitin proteasome system were also upregulated

The article says tirzepatide's dual GIP and GLP-1 mechanism engages additional metabolic and appetite-regulating circuits, and may influence glucose metabolism and gastric motility in ways that differ from GLP-1 activation alone

A decrease in GSH levels can upregulate the expression levels of Fas and PD-L1 in tumor cells, and block the PD-1/PD-L1 pathway through BMS-1