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Acknowledgments We gratefully acknowledge Wuhan Maiwei Metabolomics Co., Ltd., for providing technical support in mass spectrometry-based proteomic and metabolomic analysis, and Editage (www.editage.cn) for professional English language editing

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Thus, these results suggest that GLP-1RAs exhibit superior preventive effects on atherosclerotic CV events and can improve CV prognosis in T2D patients with a previous history of CV events (except ACS), and that such treatment effects could become apparent by, for example, comparing the results of CV outcomes trials with another class of incretin-based agents, namely dipeptidyl peptidase-4 (DPP-4) inhibitors [31,32,33]

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