In experimental models, OLETF rats have shown local RAS activation, which resulted in oxidative stress and kidney progressive damage, whereas treatment with dapagliflozin remarkably lowered the urinary ANG II and AGT levels ( However, the renal beneficial effect of SGLT2-i has been definitely reported in recent cardiovascular outcome clinical trials and further confirmed in CREDENCE, DAPA-CKD, EMPA-KIDNEY, which investigated renal outcomes as primary endpoints also in non-diabetic patients with chronic kidney disease ( Indeed, there is a growing body of evidence suggesting a significant beneficial class effect associated with SGLT2 inhibition, resulting in MACE, cardiovascular death and hospitalization for heart failure (HHF) reduction, despite some variabilities in the findings provided by individual CVOTs ( In populations that largely did not suffer from HF at the time of the enrolment, treatment with empagliflozin, canagliflozin and dapagliflozin had been able to decrease the risk of new-onset HF events by about 30%
The experts perceived costs, barriers to prescription, and adherence concerns as the primary challenges
Ozempic, whether in a pill or an injection, can produce side effects in some people
They come in different dose strengths
Serious shared side effects of both medications include: inflamed pancreas (very rarely) severe allergic reaction (very rarely) You should seek urgent medical help immediately if you notice: severe or prolonged stomach pain pain that moves to the back nausea and vomiting fever swelling of face, tongue, lips, or throat trouble breathing or swallowing severe rash or hives dizziness fainting All medications can potentially have side effects, and Mounjaro and Ozempic/Wegovy are no different
