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Consider reducing to the previous tolerated dose for an additional 4 to 8 weeks before attempting re-escalation

This is what we talked about on today's episode of the GLP1 Hub podcast

In the case of sll0067, TeGST, and SeGST, serine replaces threonine in the N-capping box and phenylalanine and valine residue constitute the hydrophobic staple motif except in SeGST in which leucine is present instead of phenylalanine

The only apparent difference was an increase in diastolic blood pressure before the beginning of the placebo treatment in patients who received dulaglutide first

From the co-localization analysis, we infer that increased nausea or vomiting is associated with greater BMI loss efficacy (Extended Data Fig