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Int J Mol Sci (2021) 22:6297

doi 10.1053/gast.2000.16489 67 rskovCHartmannBPoulsenSSThulesenJHareKJHolstJJ

[DOI] [PMC free article] [PubMed] 19.Simon J.A., Kingsberg S.A., Goldstein I., Kim N.N., Hakim B., Millheiser L

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As expected, the three best compounds in vivo, 14 , 22 and 23 , had all (1) improved stability in NEP 24.11 degradation assays, (2) prolonged half-lives in mouse plasma and (3) decent potency