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Oxyntomodulin is a biased agonist relative to GLP-1 4 , and forms distinct and more dynamic interactions with the GLP-1R, particularly with residues at the base of the peptide binding cavity that is located above the conserved central polar network that is important for receptor activation

Wang, C.-N., Liu, Y.-J., Duan, G.-L., Zhao, W., Li, X.-H., Zhu, X.-Y., & Ni, X