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While chronic exposure might partially normalize lipid oxidation via changes in gene expression and mitochondrial remodeling, the short-term effect is logically a decrease in exercise tolerance and potentially prolonged recovery

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Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

[DOI] [Google Scholar] 21.Pickart L., Vasquez-Soltero J.M., Margolina A

However, HRT does not directly suppress appetite or improve insulin sensitivitythose mechanisms remain separate from hormonal replacement