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Steamy, wet, and humid saunas are more difficult to tolerate for some

Purine nucleoside phosphorylase (PNP) is significantly increased in IBS-C and IBS-D patients, however, it is negatively correlated with hypoxanthine concentration (Mars et al., 2020)

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Although some experimental studies have reported reduced cavernous nerve fiber density and impaired neurotransmitter release in varicocele-related settings, much of the current evidence remains derived from non-varicocele nerve injury models or broader ED research (111, 155)