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In cell proliferation assays, DES(1-3) IGF-1 is approximately 10-fold more potent than native IGF-1, but IGF-1 LR3 achieves even greater sustained activation because its prolonged presence continuously stimulates the receptor

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doi: 10.1089/thy.2021.0621 12 RozarioTDeSimoneDW

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Oct 2010;140(10):1764-1768

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