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Overall Evidence for the Use of B12 for Painful Peripheral Polyneuropathy Taking into account the above evidence, there is level III evidence overall to support the use of B12 either as monotherapy or as a combination therapy for treating neuropathic pain caused by peripheral polyneuropathy

Additionally, it exhibits protective effects against oxidative stress and has been shown to restore integrity to damaged vasculature and gastrointestinal tissues 2,3

For a 4-week protocol with daily injections, use the four-quadrant system plus one or two additional sites (posterior knee, proximal patellar tendon)

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