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doi: 10.1016/j.cellsig.2017.10.014

The synthesis method of the Cagrilintide comprises the third step of preparing 200mL of cracking reagent, adding the full-protection peptide under an ice bath condition, returning to room temperature after 0.5h, continuing to react for 2h, adding anhydrous ether for precipitation after the reaction is finished, performing centrifugal precipitation for multiple times, adding 300mL of ether each time, and drying to obtain the Cagrilintide product

BPC-157

Funding This work was supported by the CNPq/Brazil, Bill & Melinda Gates Foundation (process 401726/2015-0 APP/Call 47/2014) and the INCT/Excitotoxicity and Neuroprotection (465671/2014-4)

Khurana et al .[] studied the therapeutic effect of oral and intradermal microinjections of TA in patients of facial melasma ( n = 32 in each arm) and found that undoubtedly oral TA treatment is more efficacious