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Refining these clusters further to focus on those with higher concentrations of molecules and lower IC values proved essential

This dual-faceted ranking method successfully identified compounds with both high computational and experimental inhibitory activity, demonstrating the enhanced reliability of integrating diverse data sources

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However, the more honest metric is cost per effective dose , and here oral's lower and more variable systemic bioavailability complicates the picture: if a larger oral dose is needed to achieve a comparable systemic effect, the apparent per-milligram savings shrink